My very rudimentary nginx.conf file which I use for development on my Mac. I use a special setup with dnsmasq which redirects all URLs like foo.dev, foo.prod etc. to my localhost. I use Nginx in combination with PHP-FPM. You can do the same with Apache, see: https://gist.github.com/robertlemke/4951820

nginx.conf

worker_processes  1;

events {
    worker_connections  1024;
}


http {

    include       mime.types;
    default_type  application/octet-stream;
    sendfile        on;
    keepalive_timeout  65;

  root /Users/robert/Sites;

	server {
		listen 80;
		server_name localhost;

		location / {
			index index.php index.html;
		}

		location ~ \.php$ {
			fastcgi_pass 127.0.0.1:9000;

			include fastcgi_params;
			fastcgi_index index.php;
			try_files $uri =404;

			fastcgi_param SCRIPT_FILENAME $document_root/$fastcgi_script_name;
			fastcgi_param SCRIPT_NAME $fastcgi_script_name;
			fastcgi_param PATH_INFO $fastcgi_path_info;
		}
	}

	server {
		listen 80;

		server_name ~^(?<project>.*)\.dev$;
		root /Users/robert/Sites/$project/Web;
			
		client_max_body_size 50M;

		index index.php;

		location ~ /\. {
			deny all;
			access_log off;
			log_not_found off;
		}

		try_files $uri $uri/ /index.php?$args;

		location ~ \.php$ {
			include fastcgi_params;
			fastcgi_pass 127.0.0.1:9000;
			fastcgi_index index.php;

			fastcgi_param FLOW_CONTEXT Development;
			fastcgi_param FLOW_REWRITEURLS 1;

			fastcgi_split_path_info ^(.+\.php)(.*)$;
			fastcgi_param SCRIPT_FILENAME $document_root$fastcgi_script_name;
			fastcgi_param PATH_INFO $fastcgi_path_info;
		}

		location ~ "^/_Resources/Persistent/" {
			rewrite "(.{40})/.+\.(.+)" /_Resources/Persistent/$1.$2 break;
			rewrite "([a-z0-9]+/(.+/)?[a-f0-9]{40})/.+\.(.+)" /_Resources/Persistent/$1.$2 break;
		}

		location / {
			try_files $uri $uri/ /index.php?$args;
		}

		location ~* \.(jpg|jpeg|gif|css|png|js|ico)$ {
			access_log off;
			expires max;
		}

	}

	server {
		listen 80;

		server_name ~^(?<project>.*)\.prod$;
		root /Users/robert/Sites/$project/Web;
			
		client_max_body_size 50M;

		index index.php;

		location ~ /\. {
			deny all;
			access_log off;
			log_not_found off;
		}

		try_files $uri $uri/ /index.php?$args;

		location ~ \.php$ {
			include fastcgi_params;
			fastcgi_pass 127.0.0.1:9000;
			fastcgi_index index.php;

			fastcgi_param FLOW_CONTEXT Production;
			fastcgi_param FLOW_REWRITEURLS 1;

			fastcgi_split_path_info ^(.+\.php)(.*)$;
			fastcgi_param SCRIPT_FILENAME $document_root$fastcgi_script_name;
			fastcgi_param PATH_INFO $fastcgi_path_info;
		}

		location ~ "^/_Resources/Persistent/" {
			rewrite "(.{40})/.+\.(.+)" /_Resources/Persistent/$1.$2 break;
			rewrite "([a-z0-9]+/(.+/)?[a-f0-9]{40})/.+\.(.+)" /_Resources/Persistent/$1.$2 break;
		}

		location / {
			try_files $uri $uri/ /index.php?$args;
		}

		location ~* \.(jpg|jpeg|gif|css|png|js|ico)$ {
			access_log off;
			expires max;
		}

	}

	server {
		listen 80;

		server_name ~^(?<project>.*)\.l$;
		root /Users/robert/Sites/$project;
			
		client_max_body_size 50M;

		index index.php;

		location ~ /\. {
			deny all;
			access_log off;
			log_not_found off;
		}

		try_files $uri $uri/ /index.php?$args;

		location ~ \.php$ {
			include fastcgi_params;
			fastcgi_pass 127.0.0.1:9000;
			fastcgi_index index.php;

			fastcgi_split_path_info ^(.+\.php)(.*)$;
			fastcgi_param SCRIPT_FILENAME $document_root$fastcgi_script_name;
			fastcgi_param PATH_INFO $fastcgi_path_info;
		}

		location / {
			try_files $uri $uri/ /index.php?$args;
		}

		location ~* \.(jpg|jpeg|gif|css|png|js|ico)$ {
			access_log off;
			expires max;
		}

	}


}