See https://blog.neilsabol.site/post/yubikey-personalization-tool-yubico-powershell-command-cli-program-random-static-password-commandline/#closing-thoughts. This snippet uses the ykpersonalize (YubiKey Personalization Tool) command to generate a new static password on the Yubikey.

ykpersonalize-yubikey-generate-static-password.ps1

# Create an alias for ykpersonalize pointing the the location it is downloaded to
set-alias ykpersonalize "$env:localappdata\Programs\Yubico\bin\ykpersonalize.exe"

# Generate a random hex (AES key) to serve as entropy (randomness source) for ykpersonalize
$RandomHex = (((32)|%{((1..$_)|%{('{0:X}' -f (random(16)))})}) -Join "").ToLower()

# Run ykpersonalize to generate a random static password in Yubikey's config slot 2
ykpersonalize -2 -a"$RandomHex" -ostatic-ticket -oshort-ticket -ostrong-pw1 -ostrong-pw2 -y