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Top 200 dementia supplements (Grok AI)
Rank Supplement/Drug/Protocol Description Potential Relevance to Dementia, Alzheimer or Leukoaraiosis Status
1 Taurine Amino acid with antioxidant properties May reduce oxidative stress and support vascular health Supplement, widely available
2 NAC (N-Acetylcysteine) Precursor to glutathione, antioxidant Could mitigate inflammation and vascular damage Supplement, niche for brain
3 Piracetam Nootropic, enhances cerebral metabolism May improve cognitive function and blood flow Prescription/supplement
4 L-Theanine Amino acid from tea, promotes relaxation May reduce stress-related vascular damage Supplement, emerging
5 Magnesium Glycinate Bioavailable magnesium form Could improve cerebral blood flow and reduce damage Supplement, less common form
6 Creatine Energy metabolism enhancer May support brain energy in vascular compromise Supplement, unconventional use
7 Ashwagandha Adaptogen, reduces stress Could lower inflammation impacting vascular health Supplement, niche for brain
8 Curcumin (Theracurmin) Micronized curcumin, anti-inflammatory May reduce vascular inflammation and oxidative stress Supplement, specialized form
9 Alpha Lipoic Acid (ALA) Antioxidant, mitochondrial support Could reduce neuropathy and oxidative brain damage Supplement, niche use
10 PQQ (Pyrroloquinoline Quinone) Mitochondrial biogenesis enhancer May improve brain energy and protect against aging Supplement, experimental
11 Citicoline Choline precursor, supports brain repair Could enhance cognitive function and repair damage Supplement, emerging
12 Serrapeptase Enzyme with anti-inflammatory properties May reduce inflammation and improve circulation Supplement, niche/experimental
13 Shilajit Mineral-rich resin for vitality Could support brain energy and reduce inflammation Supplement, unconventional
14 Ecdysterone Plant-derived steroid, energy enhancer Speculative cognitive and vascular energy benefits Supplement, experimental
15 Reishi Mushroom Fungi with immune/neuroprotective effects May reduce inflammation and support brain health Supplement, emerging
16 Turkey Tail Mushroom Fungi with polysaccharides, immune support Could aid neuroprotection and reduce inflammation Supplement, niche use
17 Huperzine A Acetylcholinesterase inhibitor, cognitive enhancer May improve memory and circulation Supplement, less common
18 Phosphatidylserine Phospholipid for brain cell membranes Could support myelin health and cognitive function Supplement, niche for repair
19 Acetyl-L-Carnitine (ALCAR) Mitochondrial energy booster May enhance brain energy metabolism Supplement, unconventional
20 Lion’s Mane Mushroom Fungi stimulating nerve growth factor Could support myelin repair and neuroprotection Supplement, growing interest
21 Hydergine Ergot alkaloid derivative, cognitive enhancer May improve cerebral blood flow and oxygenation Prescription, experimental use
22 Oxiracetam Racetam family nootropic Could enhance brain metabolism and acetylcholine use Supplement, niche
23 Coluracetam Racetam family nootropic, choline uptake enhancer May improve cognitive function and mood Supplement, experimental
24 Cerebrolysin Neurotrophic peptide mixture, injectable Could promote neuroregeneration in white matter Prescription, experimental
25 C60 Olive Oil Fullerene in olive oil, antioxidant Theoretical protection against oxidative brain damage Experimental supplement
26 DMAE/Centrophenoxine Choline precursor and lipofuscin reducer May improve memory and neuronal health Supplement, niche/experimental
27 Picamilion GABA and niacin combo, neuroprotective May enhance circulation and reduce stress Supplement, uncommon
28 Vasopressin Peptide hormone, memory enhancer Could improve memory and cognitive function Prescription, experimental use
29 Avocado Oil Oil rich in oleic acid May support myelin health and brain oxygenation Supplement, unconventional
30 Neuroaid (Chinese Herbs) Herbal blend for stroke recovery Could improve vascular outcomes and circulation Supplement, niche
31 Gastrodia elata Blume (Tianma) Herb with neuroprotective effects May modulate amyloid and support cognition Supplement, emerging
32 Catalpol Iridoid glycoside from Rehmannia Could enhance angiogenesis and neuroprotection Supplement, experimental
33 Puerarin Isoflavone from Pueraria lobata May improve vascular function and reduce inflammation Supplement, niche
34 9-Methyl-β-carboline Compound increasing dopaminergic neurons Could enhance cognition and neurorepair Supplement, experimental
35 HEPPS (EPPS) Sulfonic acid buffering agent May reduce amyloid burden and vascular stress Experimental, not approved
36 TUDCA Bile acid derivative, neuroprotection May protect against neuronal damage and vascular decline Supplement, experimental
37 Vinpocetin Synthetic vincamine derivative May enhance cerebral blood flow Supplement, off-label
38 Nicergoline Ergot derivative for cerebrovascular health May enhance blood flow and neuroprotection Prescription, not widely approved
39 Rhodiola Rosea Adaptogen, stress and fatigue reducer May reduce inflammation and support vascular health Supplement, niche use
40 Bacopa Monnieri Herb with cognitive-enhancing properties Could improve memory and reduce vascular stress Supplement, emerging
41 Nicotinamide Riboside NAD+ precursor, cellular repair May mitigate age-related vascular decline Supplement, experimental
42 Methylene Blue Synthetic compound, mitochondrial enhancer Could improve cerebral oxygenation and reduce stress Experimental, off-label
43 Trodusquemine Aminosterol for protein misfolding Speculative benefit for vascular/neurodegenerative paths Experimental, not approved
44 Galantamine Cholinesterase inhibitor from snowdrop Could support cognitive function in vascular decline Prescription, off-label potential
45 Semax Synthetic peptide, neuroprotective May improve circulation and resilience to stress Experimental, limited markets
46 Sulbutiamine Synthetic thiamine derivative May boost brain energy and circulation Supplement, uncommon
47 Uridine Monophosphate Nucleotide precursor, synaptic health Could enhance myelin synthesis and repair Supplement, emerging
48 Noopept Synthetic nootropic, neuroprotection May enhance cognitive function in vascular issues Supplement, experimental
49 Oxiracetam Racetam family nootropic Could support brain metabolism and circulation Supplement, niche
50 Aniracetam Racetam family nootropic, anxiolytic Could reduce stress and support vascular brain health Supplement, niche
51 Phenylpiracetam Racetam family nootropic, stimulant May boost energy and circulation in brain Supplement, restricted in some areas
52 L-Carnosine Dipeptide with antioxidant properties Could protect against oxidative damage in white matter Supplement, less common
53 Agmatine Sulfate Neurotransmitter modulator May improve blood flow and reduce inflammation Supplement, experimental
54 Berberine Alkaloid with metabolic benefits Could reduce vascular inflammation and damage Supplement, niche for brain
55 Quercetin Flavonoid with anti-inflammatory effects May reduce oxidative stress in brain vasculature Supplement, emerging
56 Resveratrol Polyphenol with antioxidant properties Could protect against vascular aging and inflammation Supplement, niche use
57 Astaxanthin Carotenoid with potent antioxidant effects May reduce oxidative stress impacting white matter Supplement, emerging
58 Nattokinase Enzyme from fermented soy, fibrinolytic Could improve circulation and reduce vascular damage Supplement, niche/experimental
59 Luteolin Flavonoid with anti-inflammatory properties May reduce neuroinflammation in vascular conditions Supplement, less common
60 Pterostilbene Resveratrol analog, antioxidant Could protect against vascular and neuronal decline Supplement, experimental
61 Choline Bitartrate Choline source for brain health May support myelin and cognitive function Supplement, less common form
62 Inositol Sugar alcohol with neuroprotective potential Could stabilize mood and support brain health Supplement, niche
63 Cordyceps Fungi with energy and immune benefits May enhance brain energy and reduce inflammation Supplement, emerging
64 Maitake Mushroom Fungi with immune and metabolic support Could reduce inflammation in vascular brain issues Supplement, niche
65 Chaga Mushroom Fungi with antioxidant properties May protect against oxidative stress in brain Supplement, emerging
66 Schisandra Chinensis Adaptogen with neuroprotective effects Could reduce stress and support vascular health Supplement, niche
67 Holy Basil (Tulsi) Adaptogen with anti-inflammatory properties May lower inflammation impacting white matter Supplement, emerging
68 Gotu Kola Herb with circulatory and cognitive benefits Could improve blood flow and neuronal health Supplement, niche
69 Ginseng (Panax) Adaptogen with cognitive and energy benefits May enhance circulation and reduce vascular stress Supplement, less common use
70 Maca Root Adaptogen for energy and hormonal balance Speculative benefit for brain energy and circulation Supplement, niche
71 Mucuna Pruriens L-Dopa source, dopamine precursor Could support neuronal health in vascular decline Supplement, emerging
72 Tyrosine Amino acid, dopamine precursor May boost cognitive function in stress-related damage Supplement, niche use
73 Phenylethylamine (PEA) Trace amine, mood and focus enhancer Speculative cognitive support in vascular issues Supplement, experimental
74 Theobromine Alkaloid from cocoa, mild stimulant Could improve circulation and brain energy Supplement, less common
75 Acetyl-L-Tyrosine Bioavailable tyrosine form May enhance brain function in vascular stress Supplement, niche
76 Betaine (TMG) Methyl donor, supports methylation Could reduce homocysteine-related vascular damage Supplement, emerging
77 Hordenine Alkaloid with stimulant properties Speculative energy and circulation benefits Supplement, niche/experimental
78 Kanna (Sceletium Tortuosum) Herb with mood-enhancing effects Could reduce stress impacting vascular health Supplement, emerging
79 Polygala Tenuifolia Herb with cognitive and neuroprotective effects May support brain health in vascular conditions Supplement, niche
80 Tongkat Ali Herb for energy and hormonal support Speculative cognitive and vascular energy benefits Supplement, experimental
81 Black Seed Oil (Nigella Sativa) Oil with anti-inflammatory properties Could reduce inflammation in brain vasculature Supplement, emerging
82 Pine Bark Extract Similar to pycnogenol, antioxidant May support endothelial function and reduce damage Supplement, niche
83 Saffron Spice with antidepressant and neuroprotective effects Could reduce inflammation and support brain health Supplement, emerging
84 Cat’s Claw Herb with anti-inflammatory and immune effects Could reduce neuroinflammation in vascular issues Supplement, emerging
85 Eleuthero (Siberian Ginseng) Adaptogen for stress and energy May enhance circulation and reduce vascular stress Supplement, niche
86 Gynostemma Pentaphyllum Adaptogen with antioxidant properties Could protect against oxidative stress in brain Supplement, emerging
87 Hawthorn Berry Herb for cardiovascular support May improve cerebral blood flow and vascular health Supplement, niche
88 Lemon Balm Herb with calming and cognitive effects Could reduce stress-related vascular damage Supplement, emerging
89 Passionflower Herb with calming properties May lower stress impacting white matter health Supplement, niche
90 Skullcap Herb with neuroprotective and calming effects May reduce inflammation and support brain health Supplement, niche
91 St. John’s Wort Herb with antidepressant properties Speculative benefit for mood and vascular stress Supplement, emerging
92 Valerian Root Herb with sedative and calming effects Could reduce stress-related vascular damage Supplement, niche
93 Yohimbe Alkaloid with stimulant and circulatory effects Speculative benefit for brain circulation Supplement, experimental
94 Ziziphus Jujuba Herb with calming and neuroprotective effects May reduce stress and support brain health Supplement, niche
95 Artemisinin Compound from wormwood, anti-inflammatory Could reduce inflammation in vascular brain issues Supplement, experimental
96 Boswellia Serrata Resin with anti-inflammatory properties May reduce neuroinflammation in white matter Supplement, emerging
97 Bromelain Enzyme from pineapple, anti-inflammatory Could improve circulation and reduce inflammation Supplement, niche
98 Capsaicin Compound from chilies, circulation enhancer Speculative benefit for brain blood flow Supplement, experimental
99 Chrysin Flavonoid with anti-inflammatory effects May reduce oxidative stress in brain vasculature Supplement, niche
100 Ellagic Acid Polyphenol with antioxidant properties Could protect against vascular aging and inflammation Supplement, emerging
101 Forskolin Compound from coleus, cyclic AMP enhancer Speculative benefit for brain energy and circulation Supplement, experimental
102 Genistein Isoflavone with antioxidant properties May reduce inflammation in vascular conditions Supplement, niche
103 Hesperidin Flavonoid with vascular protective effects Could improve cerebral blood flow and reduce damage Supplement
104 Icariin Flavonoid from horny goat weed, circulatory effects Speculative benefit for brain circulation Supplement, experimental
105 Kaempferol Flavonoid with anti-inflammatory properties May reduce oxidative stress in brain vasculature Supplement, niche
106 Naringin Flavonoid with antioxidant and vascular effects Could protect against vascular damage in white matter Supplement, emerging
107 Oleuropein Polyphenol from olive leaf, antioxidant May reduce inflammation and support vascular health Supplement, niche
108 Silymarin Milk thistle extract, antioxidant Could protect against oxidative stress in brain Supplement, emerging
109 Adrafinil Prodrug to modafinil, wakefulness enhancer May boost cognitive function in vascular decline Supplement, experimental
110 Armodafinil Enantiomer of modafinil, wakefulness May enhance brain energy and focus Prescription, off-label
111 Selegiline MAO-B inhibitor, neuroprotection Could support dopamine and brain health Prescription, experimental use
112 Rasagiline MAO-B inhibitor, neuroprotection May protect against neuronal damage Prescription, niche
113 Memantine NMDA receptor antagonist Could reduce excitotoxicity in vascular decline Prescription, off-label
114 Donepezil Cholinesterase inhibitor May support cognition in vascular issues Prescription, niche
115 Rivastigmine Cholinesterase inhibitor Could enhance brain function in decline Prescription, off-label
116 Tianeptine Atypical antidepressant May reduce stress and support neuroprotection Prescription, experimental
117 Bromantane Synthetic adaptogen, stimulant May boost energy and resilience in brain Experimental, limited
118 Dihexa Synthetic peptide, neurogenic Could promote brain repair and growth Experimental, not approved
119 NSI-189 Neurogenic compound May support brain regeneration Experimental, limited
120 PRL-8-53 Synthetic nootropic Could enhance memory in vascular decline Experimental, niche
121 Cyclazodone Stimulant, cognitive enhancer May boost brain function in stress Experimental, not approved
122 Sunifiram Ampakine, cognitive enhancer Could improve memory and brain health Experimental, limited
123 Unifiram Ampakine, cognitive enhancer May support cognitive function Experimental, niche
124 Fasoracetam Racetam nootropic Could enhance memory and reduce stress Experimental, emerging
125 IDRA-21 Ampakine, cognitive enhancer May boost brain function in decline Experimental, limited
126 Nefiracetam Racetam nootropic Could enhance memory and brain health Experimental, niche
127 Pramiracetam Racetam nootropic, cognitive enhancer May improve focus and circulation Supplement, experimental
128 Oxaloacetate Metabolic intermediate Could support brain energy and reduce inflammation Supplement, emerging
129 7,8-Dihydroxyflavone Flavonoid, BDNF mimetic May promote neuroprotection and repair Experimental, niche
130 Selank Synthetic peptide, anxiolytic Could reduce stress-related vascular damage Experimental, limited
131 Phenibut GABA analog, anxiolytic May reduce stress impacting vascular health Supplement, restricted
132 Kratom Herb with opioid-like effects Speculative cognitive and energy benefits Supplement, controversial
133 Yerba Mate Herb, stimulant and antioxidant Could support brain health and vascular function Supplement, emerging
134 Guarana Herb, caffeine source May boost brain energy and circulation Supplement, niche
135 Catuaba Bark Herb with neuroprotective potential Speculative benefit for brain circulation Supplement, emerging
136 Theacrine Caffeine-like compound, energy boost Could support brain energy in vascular decline Supplement, niche
137 Nobiletin Flavonoid from citrus peels May improve cerebral blood flow Supplement, experimental
138 Gastrodin Compound from Gastrodia elata Could support neuroprotection and circulation Supplement, emerging
139 Fisetin Flavonoid, senolytic properties May mitigate age-related vascular damage Supplement, niche
140 Apigenin Flavonoid, neuroprotective Could support brain health and reduce inflammation Supplement, emerging
141 Baicalein Flavonoid from Scutellaria May reduce oxidative stress in brain Supplement, niche
142 Myricetin Flavonoid, antioxidant Could support vascular health in brain Supplement, emerging
143 Horny Goat Weed Herb with icariin, circulatory effects Speculative benefit for brain circulation Supplement, niche
144 Damiana Herb with mood-enhancing properties Could reduce stress impacting vascular health Supplement, emerging
145 Grape Seed Extract Polyphenol-rich extract, antioxidant May improve vascular integrity and reduce inflammation Supplement, niche
146 Milk Thistle Herb with silymarin, liver and brain support Could protect against oxidative stress in brain Supplement, emerging
147 Olive Leaf Extract Source of oleuropein, antioxidant May support vascular health and reduce inflammation Supplement, niche
148 Pomegranate Extract Polyphenol-rich, antioxidant Could protect against vascular aging and damage Supplement, emerging
149 Green Tea Extract (EGCG) Catechin with antioxidant properties May reduce inflammation and support brain health Supplement, niche
150 Rosemary Extract Herb with carnosic acid, neuroprotective Could enhance circulation and reduce oxidative stress Supplement, emerging
151 Sage Extract Herb with cognitive-enhancing effects May support memory and vascular brain health Supplement, niche
152 Turmeric (Bioavailable forms) Curcumin source, anti-inflammatory Could reduce neuroinflammation in white matter Supplement, emerging
153 Cinnamon Extract Spice with anti-inflammatory effects May improve circulation and reduce vascular damage Supplement, niche
154 Clove Extract Spice with eugenol, antioxidant Could protect against oxidative stress in brain Supplement, emerging
155 Oregano Extract Herb with antimicrobial and antioxidant effects May reduce inflammation in vascular conditions Supplement, niche
156 Thyme Extract Herb with thymol, antioxidant Could support brain health and reduce inflammation Supplement, emerging
157 Peppermint Extract Herb with menthol, circulatory effects Speculative benefit for brain circulation Supplement, niche
158 Ginger Extract Spice with gingerols, anti-inflammatory May improve circulation and reduce neuroinflammation Supplement, emerging
159 Garlic Extract Source of allicin, cardiovascular support Could enhance cerebral blood flow and vascular health Supplement, niche
160 Cayenne Pepper Source of capsaicin, circulatory enhancer Speculative benefit for brain blood flow Supplement, emerging
161 Blueberry Extract Rich in anthocyanins, antioxidant May protect against vascular aging and inflammation Supplement, niche
162 Bilberry Extract Similar to blueberry, vascular support Could improve circulation and reduce oxidative stress Supplement, emerging
163 Acai Berry Extract Antioxidant-rich berry May support brain health and vascular integrity Supplement, niche
164 Goji Berry Extract Berry with neuroprotective compounds Could reduce inflammation and support brain health Supplement, emerging
165 Cranberry Extract Rich in proanthocyanidins, antioxidant May improve vascular health and reduce inflammation Supplement, niche
166 Elderberry Extract Antiviral and antioxidant properties Could protect against oxidative stress in brain Supplement, emerging
167 Blackcurrant Extract Rich in anthocyanins, vascular support May enhance circulation and brain health Supplement, niche
168 Raspberry Ketones Phenolic compound, metabolic enhancer Speculative benefit for brain energy and circulation Supplement, experimental
169 Mangosteen Extract Rich in xanthones, antioxidant Could reduce inflammation in vascular brain issues Supplement, emerging
170 Noni Fruit Extract Herb with antioxidant properties May support brain health and reduce inflammation Supplement, niche
171 Sea Buckthorn Berry with omega-7 and antioxidants Could protect against vascular damage and inflammation Supplement, emerging
172 Chlorella Algae with detoxifying properties May reduce oxidative stress impacting white matter Supplement, niche
173 Spirulina Algae with phycocyanin, antioxidant Could support brain health and reduce inflammation Supplement, emerging
174 Wheatgrass Rich in chlorophyll, detoxifier Speculative benefit for brain energy and circulation Supplement, niche
175 Barley Grass Grass with antioxidant enzymes May reduce inflammation and support vascular health Supplement, emerging
176 Alfalfa Herb with nutrient density Could support brain health and reduce inflammation Supplement, niche
177 Moringa Oleifera Plant with anti-inflammatory compounds May protect against oxidative stress in brain Supplement, emerging
178 Matcha Concentrated green tea, antioxidant Could enhance circulation and reduce inflammation Supplement, niche
179 Rooibos Herb with antioxidant polyphenols May support vascular health and reduce oxidative stress Supplement, emerging
180 Hibiscus Herb with antihypertensive effects Could improve cerebral blood flow and vascular health Supplement, niche
181 Dandelion Root Herb with detoxifying properties Speculative benefit for brain circulation and health Supplement, emerging
182 Nettle Leaf Herb with anti-inflammatory effects May reduce inflammation in vascular conditions Supplement, niche
183 Burdock Root Herb with detoxifying and antioxidant effects Could support brain health and reduce inflammation Supplement, emerging
184 Astragalus Herb with immune and vascular support May enhance circulation and protect brain health Supplement, niche
185 Echinacea Herb with immune-boosting properties Speculative benefit for reducing inflammation in brain Supplement, emerging
186 Goldenseal Herb with berberine, anti-inflammatory Could reduce vascular inflammation and damage Supplement, niche
187 Feverfew Herb with anti-inflammatory effects May reduce neuroinflammation in white matter Supplement, emerging
188 Chamomile Herb with calming and anti-inflammatory effects Could reduce stress-related vascular damage Supplement, niche
189 Licorice Root Herb with glycyrrhizin, anti-inflammatory May support vascular health and reduce inflammation Supplement, emerging
190 Slippery Elm Herb with mucilage, soothing properties Speculative benefit for brain health and inflammation Supplement, niche
191 Marshmallow Root Herb with mucilage, anti-inflammatory Could reduce inflammation impacting brain health Supplement, emerging
192 Plantain Leaf Herb with wound-healing properties Speculative benefit for vascular and brain health Supplement, niche
193 Yarrow Herb with anti-inflammatory and circulatory effects May improve circulation and reduce inflammation Supplement, emerging
194 Horehound Herb with expectorant and anti-inflammatory effects Could support brain health and reduce inflammation Supplement, niche
195 Red Yeast Rice Fermented rice with monacolin K, cholesterol support Could improve vascular health and reduce inflammation Supplement, emerging
196 White Willow Bark Herb with salicin, anti-inflammatory May reduce vascular inflammation and support circulation Supplement, niche
197 Guggul Extract Resin with guggulsterones, lipid support Could enhance vascular function and reduce inflammation Supplement, emerging
198 Bitter Melon Extract Herb with blood sugar regulation effects Speculative benefit for vascular health and brain energy Supplement, niche
199 Fenugreek Extract Herb with anti-inflammatory and metabolic effects May support circulation and reduce oxidative stress Supplement, emerging
200 Coleus Forskohlii Herb with forskolin, cyclic AMP enhancer Could improve brain energy and vascular function Supplement, niche
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