Setup cx_Oracle with Instantclient 12.1 - download the instantclient and sdk from http://www.oracle.com/technetwork/topics/linuxx86-64soft-092277.html - extract and then place these scripts in the directory - run install-cx_Oracle.sh - you will need to source envoracle.sh to use cx_Oracle or source from your .bashrc

envoracle.sh

#!/bin/bash
DIR="$( cd "$( dirname "${BASH_SOURCE[0]}" )" && pwd )"
export ORACLE_HOME=${DIR}
export LD_LIBRARY_PATH=${DIR}:$LD_LIBRARY_PATH

install-cx_Oracle.sh

#!/bin/bash
VERSION=5.1.3
DIR="$( cd "$( dirname "${BASH_SOURCE[0]}" )" && pwd )"
cd ${DIR}

FILENAME=cx_Oracle-${VERSION}.tar.gz
URL=https://pypi.python.org/packages/source/c/cx_Oracle/${FILENAME}

if [ ! -f ${FILENAME} ]; then
    curl ${URL} -o ${FILENAME}
fi

source envoracle.sh
ln -s libclntsh.so.12.1 libclntsh.so
ln -s libclntshcore.so.12.1 libclntshcore.so
ln -s libocci.so.12.1 libocci.so

rm -r -f cx_Oracle-${VERSION}
tar xvfz ${FILENAME}
cd cx_Oracle-${VERSION}
python setup.py build
python setup.py install