I have a notebook connected to a port replicator. I want to use the build-in speakers and microfone and not the external ones. If I boot my notebook in my port replicator Ubuntu changes the devices to external.
- Find your internal speaker
 
pactl list short sinks
0	alsa_output.usb-Generic_USB_Audio_201405280001-00.analog-stereo	module-alsa-card.c	s16le 2ch 44100Hz	SUSPENDED
1	alsa_output.pci-0000_00_1f.3.analog-stereo	module-alsa-card.c	s16le 2ch 44100Hz	SUSPENDED
- 
Set your internal speaker as default
pactl set-default-sink <DEVICE>e.g.pactl set-default-sink alsa_output.pci-0000_00_1f.3.analog-stereo - 
Add to "Startup Applications" ("Startprogramme" in German)
 
- Open the application "Startup Applications" (Should be preinstalled on Ubuntu)
 - Click on "Add"
 - Give your startup item a name
 - Copy your command from above into the command field.
 - Click on "Save".
 
- Find your internal microfone
 
pactl list short sources
0	alsa_output.usb-Generic_USB_Audio_201405280001-00.analog-stereo.monitormodule-alsa-card.c	s16le 2ch 44100Hz	SUSPENDED
1	alsa_input.usb-Generic_USB_Audio_201405280001-00.iec958-stereo	module-alsa-card.c	s16le 2ch 44100Hz	RUNNING
2	alsa_output.pci-0000_00_1f.3.analog-stereo.monitor	module-alsa-card.c	s16le 2ch 48000Hz	SUSPENDED
3	alsa_input.pci-0000_00_1f.3.analog-stereo	module-alsa-card.c	s16le 2ch 44100Hz	SUSPENDED
- 
Set your internal speaker as default
pactl set-default-source <DEVICE>e.g.pactl set-default-source alsa_input.pci-0000_00_1f.3.analog-stereo - 
Repeat step 3.
 



Edit
etc/pulse/default.pais the better solution. However, the comments above seem not working in my case Ubuntu 20.04.4 (desktop with sound card + web cam + USB headset) because:set-default-...alone is not enough, I end up with two devices enabled. The one pre-selected by PulseAudio (which I don't know based on which criteria) and the one I set byset-default-...The working solution for me is:
RUNNINGas status)/etc/pulse/default.paexplicitly suspend the devices selected by PulseAudio andset-defaultthe one you wantpulseaudio --kill && pulseaudio --startwould be enough but in my case I tested the real use-case with a reboot.Reference: Ubuntu manual - pactl