add to ~/.config/karabiner/assets/complex_modifications

cmd-shift-e-rule.json

{
	"title": "Rules for Karabiner-Elements | Tested Version: 11.6.0",
	"rules": [
		{
			"description": "cmd-shift-e spotlight",
			"manipulators": [
				{
					"from": {
						"key_code": "e",
						"modifiers": {
							"mandatory": ["command", "shift"]
						}
					},
					"to": [
						{
							"shell_command": "osascript -e ' tell application \"System Events\" to key code 49 using {command down} '"
						}
					],
					"type": "basic"
				}
			]
		}
	]
}